Last edited by Arahn
Thursday, April 23, 2020 | History

4 edition of Tumor specific transplantation antigen. found in the catalog.

Tumor specific transplantation antigen.

Pavel KoldovskyМЃ

Tumor specific transplantation antigen.

  • 175 Want to read
  • 20 Currently reading

Published by Springer in Berlin, New York .
Written in English

    Subjects:
  • Tumors -- Transplantation.,
  • Tumors -- Immunological aspects.

  • Edition Notes

    Bibliography: p. 63-74.

    SeriesRecent results in cancer research,, 22
    Classifications
    LC ClassificationsRC261 .R35 no. 22
    The Physical Object
    Pagination74 p.
    Number of Pages74
    ID Numbers
    Open LibraryOL4752853M
    LC Control Number78082896

      This comprehensive reference source will benefit all transplant specialists working with pharmacologic and biologic agents that modulate the immune system. Compiled by a team of world-renowned editors and contributors covering the fields of transplantation, nephrology, pharmacology, and immunology, the book covers all anti-rejection drugs according to a set template and includes the . A unique aspect to our approach for adoptive T cell therapy is the use of tumor specific CD4 + Th1 cells which may enhance anti-tumor efficacy. Adoptive T cell therapy strategies have largely focused on the infusion of tumor antigen specific cytotoxic T cells (CTL) which can directly kill tumor cells.


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Tumor specific transplantation antigen. by Pavel KoldovskyМЃ Download PDF EPUB FB2

Tumor Specific Transplantation Antigen reviews the theories, methods, and experimental findings in the field of immunobiology of tumors with particular focus on.

Purchase Tumor Specific Transplantation Antigen - 1st Edition. Print Book & E-Book. ISBNBook Edition: 1. Tumor Specific Transplantation Antigen reviews the theories, methods, and experimental findings in the field of immunobiology of tumors with particular focus on Manufacturer: Springer.

Tumor antigens are proteins, glycoproteins, glycolipids, or carbohydrates expressed on the surface of tumor cells (Fig. They include both tumor-specific antigens restricted to tumor cells and tumor-associated antigens present on both tumor cells and normal cells.

Tumor antigens can be exploited for both diagnostic and therapeutic purposes. Genre/Form: Fulltext Internet Resources: Additional Physical Format: Online version: Koldovský, Pavel.

Tumor specific transplantation antigen. Berlin, New York. Get this from a library. Tumor specific transplantation antigen. [P Koldovsky] -- Tumor Specific Transplantation Antigen reviews the theories, methods, and experimental findings in the field of immunobiology of tumors with particular focus on the tumor antigen responsible for.

Tumor Specific Transplantation Antigen. by Pavel Koldovsky. Recent Results in Cancer Research (Book 22) Thanks for Sharing. You submitted the following rating and review. We'll publish them on our site once we've reviewed : Springer Berlin Heidelberg.

Tumor Specific Transplantation Antigen. Authors (view affiliations) Search within book. Front Matter. Pages i PDF. Pavel Koldovský. Pages Back Matter. Pages PDF.

About this book. Keywords. Antigen neoplasm transplantation tumor. Authors and affiliations. Pavel Koldovský. Tumor Specific Transplantation Antigen reviews the theories, methods, and experimental findings in the field of immunobiology of tumors with particular focus on the tumor Tumor specific transplantation antigen.

book responsible for transplantation resistance. The monograph presents d. Tumor Specific Transplantation Antigen. por Pavel Koldovsky. Recent Results in Cancer Research (Book 22) ¡Gracias por compartir.

Has enviado la siguiente calificación y reseña. Lo publicaremos en nuestro sitio después de haberla : Springer Berlin Heidelberg. Cancer-Germline Genes. Another important source of tumor specific antigens is the cancer-germline genes (Figure 1).They include the melanoma-antigen encoding (MAGE) genes, comprising 25 functional genes clustered in three regions of the X chromosome: MAGEA, MAGEB, and MAGEC [49–51].Other cancer-germline gene families on the X chromosome include the BAGE [], Cited by: Tumor associated transplantation antigens on chemically-induced tumors.

Chemically-induced tumors are different from virally-induced tumors in that they are extremely heterogeneous in their antigenic characteristics. Thus, Tumor specific transplantation antigen. book two tumors induced by the same chemical, even in the same animal, rarely share common tumor specific antigens (Figure 2).

The existence of specific tumor rejection antigens was first demonstrated with chemically induced mouse sarcomas: each tumor was found to express a different antigen [1]. Similar findings were made with ultraviolet-induced tumors [2].Author: B. Van den Eynde, B. Lethé, A. Van Pel, T. Boon, T. Boon.

In melanoma, tumor-specific antigens were discovered by culturing irradiated tumor cells with autologous lymphocytes, a reaction known as the mixed lymphocyte-tumor cell culture.

From such cultures, cytotoxic T lymphocytes could be identified that would kill, in an MHC-restricted fashion, tumor cells bearing the relevant tumor-specific by: 8. The latter is not typical of most DNA tumor viruses but reverse transcription is a very important factor in the life cycles of RNA-tumor viruses.

See below. For more information on the molecular biology of hepatitis B virus and the diseases it causes, go to chapter 18 and chap part 2. Tumor Specific Transplantation Antigen (Recent Results in Cancer Research) Pavel Koldovsky Tumor Specific Transplantation Antigen reviews the theories, methods, and experimental findings in the field of immunobiology of tumors with particular focus on the tumor antigen responsible for transplantation.

A patient with B cell lymphoma is receiving therapy aimed at targeting the (unique) surface immunoglobulin expressed on his tumor cells. Used in this way, the immunoglobulin is an example of A. An oncofetal antigen B. A virally induced tumor antigen.

The Transplant Immunology and Immunogenetics Laboratory About Transplant Immunology and Immunogenetics The immune system is designed to protect us from harmful viruses, bacteria, and malignant tumors. - - - Different mechanisms generate tumor-specific transplantation antigens (TSTAs) and tumor-associated transplantation antigens (TATAs).

The latter are more common. - The immune response may play a role in selecting for tumor cells expressing lower levels of class I MHC molecules by preferentially eliminating those cells expressing high. Potent antigen-specific cytotoxic T lymphocytes were generated following heterologous boosting with poxvirus vectors.

This response was not observed with any of the homologous boosting regimens. 3. The immune system can be activated by external stimuli to effectively kill tumor cells and eradicate tumors.

Tumor Antigens 1. Tumor-Specific Transplantation Antigens (TSTAs): Antigen that are expressed on tumor cells but not on normal cells were called tumor-specific.

Tumor Antigens 2. T cells are genetically engineered to express chimeric antigen receptors specifically directed toward antigens on a patient's tumor cells, then infused into the patient where they attack and kill the cancer cells.

Adoptive transfer of T cells expressing CARs is a promising anti-cancer therapeutic, because CAR-modified T cells can be engineered to target virtually any tumor associated antigen. The immune responses to transplanted organs and to cancer cells are both important medical issues.

With the use of tissue typing and anti-rejection drugs, transplantation of organs and the control of the anti-transplant immune response have made huge strides in the past 50 years.

Cancer Vaccines and Tumor Immunity offers a review of the basic scientific discoveries that have moved forward into clinical trials. Presented in the context of real-world human research and experimentation, these major scientific advances demonstrate how our understanding of immune activation, T-regulatory cells, and autoimmunity will impact cancer vaccine design.

Transplantation Immunology Mitchell S. Cairo, MD Professor of Pediatrics, Medicine and Pathology Chief, Division, Pediatric Blood & Marrow Transplantation Children’s Hospital New York Presbyterian Tel – Fax – E-mail – [email protected] • Understand the File Size: 1MB.

Tumor antigen is an antigenic substance produced in tumor cells, i.e., it triggers an immune response in the host. Tumor antigens are useful tumor markers in identifying tumor cells with diagnostic tests and are potential candidates for use in cancer therapy.

The field of cancer immunology studies such topics.‎Mechanism of tumor ‎Classification of tumor ‎Types ‎Importance of. The tumor-specific transplantation antigen (TSTA), which appears on papovavirus-induced sarcomas of the hamster, has been demonstrated to be common in any cell type transformed by a given virus.

Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation provides clinical and scientific researchers with a deep understanding of the current research in this field and the implications for translational practice.

By providing an overview of the immune biology of HSCT, an explanation of immune rejection, and detail on antigens and their role in HSCT success, this book embraces.

DOI: /JCO Journal of Clinical Oncology - published online before print PMID: Vaccination With Patient-Specific Tumor-Derived Antigen in First Remission Improves Disease-Free Survival in Follicular LymphomaCited by: antigen [an´tĭ-jen] any substance capable, under appropriate conditions, of inducing a specific immune response and reacting with the products of that response; that is, with specific antibody or specifically sensitized T lymphocytes, or both.

Antigens may be soluble substances, such as toxins and foreign proteins, or particulates, such as bacteria. Transplantation Transplantation motherapy, (2) to establish a graft-versus-leukemia or tumor (GVL or GVT) reaction, or (3) to replace diseased tissues of hematologic and CD antigen, the absence of lineage-specific antigens, and high content of aldehyde dehydrogenase and (2) the exclusion of.

The tumor-specific transplantation antigen (TSTA), which appears on papovavirus-induced sarcomas of the hamster, has been demonstrated to be common in any cell type transformed by a given virus.

Other studies have suggested that cell-free TSTA has been successfully isolated from mouse sarcoma cells induced in vitro by simian virus 40 (SV40). Finally in the s, the discovery of human tumor antigens by the Belgian/German collaboration of the research teams of Thiery Boon and Alexander Knuth brought respectability to the field of tumor immunology, and allowed for the first time conceptually solid vaccine trials that used specific tumor antigen :   EL-4 tumor growth was markedly reduced in BCDM relative to WT mice.

However, EL-4 tumors grew normally in B cell receptor (BCR) deficient transgenic MD4 B cells with BCR specificity for an epitope on hen egg lysozyme. Thus, it appeared that B cell facilitation of tumor growth was occurring through antigen non-specific interactions with T by: Dendritic cells (DC) are professional antigen presenting cells that are crucial for the induction of anti-tumor T cell responses.

As a consequence, research has focused on the harnessing of DCs for therapeutic interventions. Although current strategies employing ex vivo-generated and tumor-antigen loaded DCs have been proven feasible, there are still many obstacles to overcome in order to Cited by: 9.

Chimeric antigen receptors (CARs) consist of an antigen recognition moiety combined with T-cell signaling domains. CARs are capable of activating T cells in an antigen-specific manner. Expression of the CD19 antigen is limited to B cells and perhaps follicular dendritic cells.

Most malignant B. ABO blood type, in which individuals are type A, B, AB, or O according to their genetics, is one example. A separate antigen system seen on red blood cells is the Rh antigen. When someone is “A positive” for example, the positive refers to the presence of the Rh antigen, whereas someone who is “A negative” would lack this molecule.

CAR T cells are autologous T cells genetically modified to target a specific tumor antigen. Patient lymphocytes are collected via apheresis and purified, after which they are transduced using a lentiviral or retroviral vector that contains the chimeric gene product, which includes an extracellular domain (an anti-CD19 single-chain variable Cited by: 3.

tumour colli: An obsolete, nonspecific term for any tumour of the neck. The immune system acting via cancer immune-surveillance is considered a potential target for improving outcomes among some malignancies. The ability to harness immune cells, engineer them and educate them to target cancer cells has changed the paradigm for treating non-Hodgkin’s lymphomas (NHL) and acute lymphoblastic leukemia (ALL).

Chimeric antigen receptor (CAR) T-cell therapy has Cited by: 7. Chimeric antigen receptor (CAR) T-cell technology has seen a rapid development over the last decade mostly due to the potential that these cells may have in treating malignant diseases. It is a generally accepted principle that very few therapeutic compounds deliver a clinical response without treatment-related toxicity, and studies have shown that CAR T-cells are not an exception to this by: 9.The progression of multiple myeloma, a hematologic malignancy characterized by unregulated plasma cell growth, is associated with increasing innate and adaptive immune system dysfunction, notably in the T-cell repertoire.

Although treatment advances in multiple myeloma have led to deeper and more durable clinical responses, the disease remains incurable for most patients.

Transplantation is the process of transferring an organ or a part thereof (known as a graft) from one donor to him/herself (autologous transplantation) or to another recipient (allogenous transplantation if the individuals are not identical twins).In addition to being subject to strict legal requirements, the donor and recipient must be histocompatible in allogenous transplantations in order.